Crystal Structure of Fragment Double-D from Human Fibrin with Two Different Bound Ligands
نویسندگان
چکیده
منابع مشابه
Crystal structure of fragment double-D from human fibrin with two different bound ligands.
Factor XIII-cross-linked fragment D (double-D) from human fibrin was crystallized in the presence of two different peptide ligands and the X-ray structure determined at 2.3 A. The peptide Gly-Pro-Arg-Pro-amide, which is an analogue of the knob exposed by the thrombin-catalyzed removal of fibrinopeptide A, was found to reside in the gamma-chain holes, and the peptide Gly-His-Arg-Pro-amide, which...
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The different species of Fragment D were purified from plasmin digests of either fibrinogen or highly cross-linked fibrin and examined electrophoretically in sodium dodecyl sulfate on polyacrylamide gels before and after reduction by ,&mercaptoethanol. It was found that Fragment D from cross-linked fibrin is approximately twice the size of that from fibrinogen, which indicates that the COOH-ter...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 1998
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi985060k